General Information

  • ID:  hor002283
  • Uniprot ID:  Q5PXH1
  • Protein name:  Kisspeptin-10
  • Gene name:  KISS1
  • Organism:  Macaca mulatta (Rhesus macaque)
  • Family:  KISS1 family
  • Source:  Animal
  • Expression:  In the hypothalamus, expression increases with puberty in both male and female monkeys. Robust expression in the region of the arcuate nucleus (ARC).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Macaca (genus), Cercopithecinae (subfamily), Cercopithecidae (family), Cercopithecoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0031773 kisspeptin receptor binding
  • GO BP:  GO:0007186 G protein-coupled receptor signaling pathway; GO:0007204 positive regulation of cytosolic calcium ion concentration
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YNW
  • Length:  3(86-88)
  • Propeptide:  SVENSRPTGQQLESLDLSAPWEQSLPCTERKPSATARLSRRGASLSSPAESSGSPQRRGLSAPSSRQIPAPQGAVLVQREKDLPNYNW
  • Signal peptide:  NA
  • Modification:  T1 Phosphotyrosine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elicit the release of gonadotropin-releasing hormone
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  KISS1R
  • Target Unid:  F6YBI8
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5PXH1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002283_AF2.pdbhor002283_ESM.pdb

Physical Information

Mass: 51736 Formula: C24H27N5O6
Absent amino acids: ACDEFGHIKLMPQRSTV Common amino acids: NWY
pI: 6.09 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -190 Boman Index: -445
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: -2790 Extinction Coefficient cystines: 6990
Absorbance 280nm: 3495

Literature

  • PubMed ID:  15684075
  • Title:  Increased Hypothalamic GPR54 Signaling: A Potential Mechanism for Initiation of Puberty in Primates